Novel Quinazolin-2,4-Dione Hybrid Molecules as Possible Inhibitors Against Malaria: Synthesis and in silico Molecular Docking Studies

The research explores the synthesis of a series of novel hybrid quinazolin-2,4-dione analogs bearing acetyl/amide bridged-nitrogen heterocyclic moieties such as azetidinone, pyrrole, oxazole, oxadiazole, thiazole, pyrazole, and thiazolidine scaffolds 2-16. The newly synthesized compounds were struct...

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Bibliographic Details
Published in:Front Mol Biosci
Main Authors: Haredi Abdelmonsef, Aboubakr, Eldeeb Mohamed, Mahmoud, El-Naggar, Mohamed, Temairk, Hussain, Mohamed Mosallam, Ahmed
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Molecular Biosciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7291371/
https://ncbi.nlm.nih.gov/pubmed/32582763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.00105
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