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Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E(2) Activation in Human Podocytes

Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in Bowman’s space. Elevated Prostaglandin E2 (PGE(2)) synthesis and upregulated cyclooxygenase 2 (Cox2) are associated wit...

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Bibliografiske detaljer
Udgivet i:Cells
Main Authors: Mangelsen, Eva, Rothe, Michael, Schulz, Angela, Kourpa, Aikaterini, Panáková, Daniela, Kreutz, Reinhold, Bolbrinker, Juliane
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7290667/
https://ncbi.nlm.nih.gov/pubmed/32438662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9051256
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