Isoniazid and Rifampin-Resistance Mutations Associated With Resistance to Second-Line Drugs and With Sputum Culture Conversion

BACKGROUND: Mutations in the genes inhA, katG, and rpoB confer resistance to anti-tuberculosis (TB) drugs isoniazid and rifampin. We questioned whether specific mutations in these genes were associated with different clinical and microbiological characteristics. METHODS: In a multicountry prospectiv...

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Pubblicato in:J Infect Dis
Autori principali: Click, Eleanor S, Kurbatova, Ekaterina V, Alexander, Heather, Dalton, Tracy L, Chen, Michael P, Posey, James E, Ershova, Julia, Cegielski, J Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Major Articles and Brief Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289556/
https://ncbi.nlm.nih.gov/pubmed/32002554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiaa042
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