Sevoflurane Preconditioning Confers Delayed Cardioprotection by Upregulating AMP-Activated Protein Kinase Levels to Restore Autophagic Flux in Ischemia-Reperfusion Rat Hearts

BACKGROUND: Volatile anesthetic preconditioning confers delayed cardioprotection against ischemia/reperfusion injury (I/R). AMP-activated protein kinase (AMPK) takes part in autophagy activation. Furthermore, autophagic flux is thought to be impaired after I/R. We hypothesized that delayed cardiopro...

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Опубликовано в: :Med Sci Monit
Главные авторы: Hong, Lei, Sun, Ying, An, Jian-Zhong, Wang, Chen, Qiao, Shi-Gang
Формат: Artigo
Язык:Inglês
Опубликовано: International Scientific Literature, Inc. 2020
Предметы:
Animal Study
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7288833/
https://ncbi.nlm.nih.gov/pubmed/32476662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.922176
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