A Systematic Review of Pediatric Phase I Trials in Oncology: Toxicity and Outcomes in the Era of Targeted Therapies

BACKGROUND: Pediatric phase I oncology trials have historically focused on safety and toxicity, with objective response rates (ORRs) <10%. Recently, with an emphasis on targeted approaches, response rates may have changed. We analyzed outcomes of recent phase I pediatric oncology trials. MATERIAL...

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Publicado en:Oncologist
Autores principales: Cohen, Julia W., Akshintala, Srivandana, Kane, Eli, Gnanapragasam, Helen, Widemann, Brigitte C., Steinberg, Seth M., Shah, Nirali N.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Pediatric Oncology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7288652/
https://ncbi.nlm.nih.gov/pubmed/31943534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2019-0615
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