Retinal Degeneration Caused by Rod-Specific Dhdds Ablation Occurs without Concomitant Inhibition of Protein N-Glycosylation

Dehydrodolichyl diphosphate synthase (DHDDS) catalyzes the committed step in dolichol synthesis. Recessive mutations in DHDDS cause retinitis pigmentosa (RP59), resulting in blindness. We hypothesized that rod photoreceptor-specific ablation of Dhdds would cause retinal degeneration due to diminishe...

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Publicado no:iScience
Main Authors: Ramachandra Rao, Sriganesh, Skelton, Lara A., Wu, Fuguo, Onysk, Agnieszka, Spolnik, Grzegorz, Danikiewicz, Witold, Butler, Mark C., Stacks, Delores A., Surmacz, Liliana, Mu, Xiuqian, Swiezewska, Ewa, Pittler, Steven J., Fliesler, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7287266/
https://ncbi.nlm.nih.gov/pubmed/32526701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101198
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