Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

The emergence of antimicrobial-resistant bacteria is an increasingly serious threat to global health, necessitating the development of innovative antimicrobials. Here we report the development of a series of CRISPR-Cas13a-based antibacterial nucleocapsids, termed CapsidCas13a(s), capable of sequence...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Kiga, Kotaro, Tan, Xin-Ee, Ibarra-Chávez, Rodrigo, Watanabe, Shinya, Aiba, Yoshifumi, Sato’o, Yusuke, Li, Feng-Yu, Sasahara, Teppei, Cui, Bintao, Kawauchi, Moriyuki, Boonsiri, Tanit, Thitiananpakorn, Kanate, Taki, Yusuke, Azam, Aa Haeruman, Suzuki, Masato, Penadés, José R., Cui, Longzhu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7287087/
https://ncbi.nlm.nih.gov/pubmed/32523110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16731-6
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