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In silico analysis reveals EP300 as a panCancer inhibitor of anti-tumor immune response via metabolic modulation

The tumor immune microenvironment (TIME) of head and neck squamous cell carcinomas (HNSCC) and other solid malignancies is a key determinant of therapy response and prognosis. Among other factors, it is shaped by the tumor mutational burden and defects in DNA repair enzymes. Based on the TCGA databa...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Krupar, Rosemarie, Watermann, Christian, Idel, Christian, Ribbat-Idel, Julika, Offermann, Anne, Pasternack, Helen, Kirfel, Jutta, Sikora, Andrew G., Perner, Sven
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7287052/
https://ncbi.nlm.nih.gov/pubmed/32523042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66329-7
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