A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

Personalized cancer treatments using combinations of drugs with a synergistic effect is attractive but proves to be highly challenging. Here we present an approach to uncover the efficacy of drug combinations based on the analysis of mono-drug effects. For this we used dose-response data from pharma...

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Publicat a:Nat Commun
Autors principals: Narayan, Ravi S., Molenaar, Piet, Teng, Jian, Cornelissen, Fleur M. G., Roelofs, Irene, Menezes, Renee, Dik, Rogier, Lagerweij, Tonny, Broersma, Yoran, Petersen, Naomi, Marin Soto, Jhon Alexander, Brands, Eelke, van Kuiken, Philip, Lecca, Maria C., Lenos, Kristiaan J., In ‘t Veld, Sjors G. J. G., van Wieringen, Wessel, Lang, Frederick F., Sulman, Erik, Verhaak, Roel, Baumert, Brigitta G., Stalpers, Lucas J. A., Vermeulen, Louis, Watts, Colin, Bailey, David, Slotman, Ben J., Versteeg, Rogier, Noske, David, Sminia, Peter, Tannous, Bakhos A., Wurdinger, Tom, Koster, Jan, Westerman, Bart A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7287046/
https://ncbi.nlm.nih.gov/pubmed/32523045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16735-2
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