TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed in COVID-19 patients. However, it is unclear whether SARS-CoV-2 replicates in the human intestine and contributes to possible fecal-oral transmission. Here, we report productive infection of SARS-CoV-2 in ACE2(+)...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Immunol
Egile Nagusiak: Zang, Ruochen, Gomez Castro, Maria Florencia, McCune, Broc T., Zeng, Qiru, Rothlauf, Paul W., Sonnek, Naomi M., Liu, Zhuoming, Brulois, Kevin F., Wang, Xin, Greenberg, Harry B., Diamond, Michael S., Ciorba, Matthew A., Whelan, Sean P. J., Ding, Siyuan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Association for the Advancement of Science 2020
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7285829/
https://ncbi.nlm.nih.gov/pubmed/32404436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abc3582
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