Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer

BACKGROUNDS: Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mechanism for CRC initiation. The Wnt pathway is mainly regulated by Wnt antagonis...

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Detalles Bibliográficos
Publicado en:Clin Epigenetics
Autores principales: Boughanem, Hatim, Cabrera-Mulero, Amanda, Hernández-Alonso, Pablo, Clemente-Postigo, Mercedes, Casanueva, Felipe F., Tinahones, Francisco José, Morcillo, Sonsoles, Crujeiras, Ana B., Macias-Gonzalez, Manuel
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7285750/
https://ncbi.nlm.nih.gov/pubmed/32517740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00875-9
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