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Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

BACKGROUND: In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca(2+) signal modulator with slow-onset kinetics. In Purkinje cells of PV(−/−) mice, adaptive/homeostatic mechanisms lead to an increase in mitochondria, organelles equally capable of delayed Ca...

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Bibliografiske detaljer
Udgivet i:Mol Autism
Main Authors: Janickova, Lucia, Rechberger, Karin Farah, Wey, Lucas, Schwaller, Beat
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7285523/
https://ncbi.nlm.nih.gov/pubmed/32517751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00323-8
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