Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling

OBJECTIVE: Macrophage interleukin (IL)-10 signalling plays a critical role in the maintenance of a regulatory phenotype that prevents the development of IBD. We have previously found that anti-tumour necrosis factor (TNF) monoclonal antibodies act through Fcγ-receptor (FcγR) signalling to promote re...

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Udgivet i:Gut
Main Authors: Koelink, Pim J, Bloemendaal, Felicia M, Li, Bofeng, Westera, Liset, Vogels, Esther W M, van Roest, Manon, Gloudemans, Anouk K, van 't Wout, Angelique B, Korf, Hannelie, Vermeire, Séverine, te Velde, Anje A, Ponsioen, Cyriel Y, D'Haens, Geert RAM, Verbeek, J Sjef, Geiger, Terrence L, Wildenberg, Manon E, van den Brink, Gijs R
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2020
Fag:
Inflammatory Bowel Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7282553/
https://ncbi.nlm.nih.gov/pubmed/31506328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2019-318264
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