Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes

BACKGROUND: Glioblastoma (GBM) has one of the worst 5-year survival rates of all cancers. While genomic studies of the disease have been performed, alterations in the non-coding regulatory regions of GBM have largely remained unexplored. We apply whole-genome sequencing (WGS) to identify non-coding...

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Detalhes bibliográficos
Publicado no:Genome Biol
Principais autores: Sakthikumar, Sharadha, Roy, Ananya, Haseeb, Lulu, Pettersson, Mats E., Sundström, Elisabeth, Marinescu, Voichita D., Lindblad-Toh, Kerstin, Forsberg-Nilsson, Karin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7281935/
https://ncbi.nlm.nih.gov/pubmed/32513296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02035-x
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