Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD) – a phase II prospective randomized multicenter trial (NOA-14, ARO 2015–3, DKTK-ROG)

BACKGROUND: Whole brain radiation therapy (WBRT) is the standard therapy for multiple brain metastases. However, WBRT has a poor local tumor control and is associated with a decline in neurocognitive function (NCF). Aim of this trial is to assess the efficacy and safety of a new treatment method, th...

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Bibliographische Detailangaben
Veröffentlicht in:BMC Cancer
Hauptverfasser: Grosu, Anca-Ligia, Frings, Lars, Bentsalo, Iryna, Oehlke, Oliver, Brenner, Franziska, Bilger, Angelika, Fennell, Jamina Tara, Rothe, Thomas, Schneider-Fuchs, Sabine, Graf, Erika, Schmoor, Claudia, Beck, Jürgen, Becker, Gerhild, Bock, Michael, Egger, Karl, Urbach, Horst, Lahmann, Claas, Popp, Ilinca
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Study Protocol
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7281918/
https://ncbi.nlm.nih.gov/pubmed/32513138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07011-z
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