Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling

BACKGROUND: Dachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. However, the roles of DACH1 in intestinal cell stemness and colorectal tumorigenesis remain largely undefined. METHODS: We used immunohistochemistry, western blotting and quantitative...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Hu, Xiang, Zhang, Long, Li, Yaqi, Ma, Xiaoji, Dai, Weixing, Gao, Xiaoxue, Rao, Xinxin, Fu, Guoxiang, Wang, Renjie, Pan, Mengxue, Guo, Qiang, Xu, Xiaoya, Zhou, Yi, Gao, Jianjun, Zhang, Zhen, Cai, Sanjun, Peng, Junjie, Hua, Guoqiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7281795/
https://ncbi.nlm.nih.gov/pubmed/32512510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102800
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