Genetic Tracing of Clonal Expansion and Progression of Pancreatic Ductal Adenocarcinoma: A Case Report and Multi-Region Sequencing Analysis

Pancreatobiliary tumors frequently contain multiple malignant and precancerous lesions; however, the origin of the driver mutations and the mechanisms that underlie the generation of distinct clones within an organ field remain unclear. Herein, we describe a 76-year-old male suffering from moderatel...

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Vydáno v:Front Oncol
Hlavní autoři: Tachibana, Shion, Mizukami, Yusuke, Ono, Yusuke, Sugiyama, Yuya, Okada, Tetsuhiro, Kitazaki, Arisa, Sasajima, Junpei, Tominaga, Motoya, Sakamoto, Jun, Kimura, Keisuke, Omori, Yuko, Furukawa, Toru, Kimura, Taichi, Tanaka, Shinya, Nagashima, Kazuo, Karasaki, Hidenori, Ohta, Tomoyuki, Okumura, Toshikatsu
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280449/
https://ncbi.nlm.nih.gov/pubmed/32582528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00728
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