Cholic Acid Stimulates MMP-9 in Human Colon Cancer Cells via Activation of MAPK, AP-1, and NF-κB Activity

Matrix metalloproteinase-9 (MMP-9) plays a crucial role in cell invasion and cancer metastasis. In this study, we showed that cholic acid (CA), a major primary bile acid, can induce MMP-9 expression in colon cancer HT29 and SW620 cells. CA increased reactive oxygen species (ROS) production and also...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Li, Shinan, Ung, Trong Thuan, Nguyen, Thi Thinh, Sah, Dhiraj Kumar, Park, Seon Young, Jung, Young Do
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279292/
https://ncbi.nlm.nih.gov/pubmed/32408577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21103420
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