Cilastatin Preconditioning Attenuates Renal Ischemia-Reperfusion Injury via Hypoxia Inducible Factor-1α Activation

Cilastatin is a specific inhibitor of renal dehydrodipeptidase-1. We investigated whether cilastatin preconditioning attenuates renal ischemia-reperfusion (IR) injury via hypoxia inducible factor-1α (HIF-1α) activation. Human proximal tubular cell line (HK-2) was exposed to ischemia, and male C57BL/...

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Publicat a:Int J Mol Sci
Autors principals: Hong, Yu Ah, Jung, So Young, Yang, Keum Jin, Im, Dai Sig, Jeong, Kyung Hwan, Park, Cheol Whee, Hwang, Hyeon Seok
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7279043/
https://ncbi.nlm.nih.gov/pubmed/32438631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21103583
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