Intronic Alternative Polyadenylation in the Middle of the DMD Gene Produces Half-Size N-Terminal Dystrophin with a Potential Implication of ECG Abnormalities of DMD Patients

The DMD gene is one of the largest human genes, being composed of 79 exons, and encodes dystrophin Dp427m which is deficient in Duchenne muscular dystrophy (DMD). In some DMD patient, however, small size dystrophin reacting with antibody to N-terminal but not to C-terminal has been identified. The m...

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Bibliographic Details
Published in:	Int J Mol Sci
Main Authors:	Rani, Abdul Qawee Mahyoob, Yamamoto, Tetsushi, Kawaguchi, Tatsuya, Maeta, Kazuhiro, Awano, Hiroyuki, Nishio, Hisahide, Matsuo, Masafumi
Format:	Artigo
Language:	Inglês
Published:	MDPI 2020
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7278912/ https://ncbi.nlm.nih.gov/pubmed/32443516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21103555
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Intronic Alternative Polyadenylation in the Middle of the DMD Gene Produces Half-Size N-Terminal Dystrophin with a Potential Implication of ECG Abnormalities of DMD Patients

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