MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment

Limited knowledge of the mechanisms that govern the self-renewal of human haematopoietic stem cells (HSCs), and why this fails in culture, have impeded the expansion of HSCs for transplantation(1). Here we identify MLLT3 (also known as AF9) as a crucial regulator of HSCs that is highly enriched in h...

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Pubblicato in:Nature
Autori principali: Calvanese, Vincenzo, Nguyen, Andrew T., Bolan, Timothy J., Vavilina, Anastasia, Su, Trent, Lee, Lydia K., Wang, Yanling, Lay, Fides D., Magnusson, Mattias, Crooks, Gay M., Kurdistani, Siavash K., Mikkola, Hanna K. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7278275/
https://ncbi.nlm.nih.gov/pubmed/31776511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1790-2
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