The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives

The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple cytoprotective responses through the induction of a complex transcriptional program that ultimately renders cancer cells resistant to oxidative, metabolic and therapeutic stress. Interestingly, accumulating evidence in...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Panieri, Emiliano, Telkoparan-Akillilar, Pelin, Suzen, Sibel, Saso, Luciano
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7277620/
https://ncbi.nlm.nih.gov/pubmed/32443774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10050791
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