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Divalent cations bind to phosphoinositides to induce ion and isomer specific propensities for nano-cluster initiation in bilayer membranes

We report all-atom molecular dynamics simulations of asymmetric bilayers containing phosphoinositides in the presence of monovalent and divalent cations. We have characterized the molecular mechanism by which these divalent cations interact with phosphoinositides. Ca(2+) desolvates more readily, con...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:R Soc Open Sci
Prif Awduron: Bradley, Ryan P., Slochower, David R., Janmey, Paul A., Radhakrishnan, Ravi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Royal Society 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7277276/
https://ncbi.nlm.nih.gov/pubmed/32537210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.192208
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