Linker histone epitopes are hidden by in situ higher-order chromatin structure

BACKGROUND: Histone H1 is the most mobile histone in the cell nucleus. Defining the positions of H1 on chromatin in situ, therefore, represents a challenge. Immunoprecipitation of formaldehyde-fixed and sonicated chromatin, followed by DNA sequencing (xChIP-seq), is traditionally the method for mapp...

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Publicado en:Epigenetics Chromatin
Autores principales: Teif, Vladimir B., Gould, Travis J., Clarkson, Christopher T., Boyd, Logan, Antwi, Enoch B., Ishaque, Naveed, Olins, Ada L., Olins, Donald E.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276084/
https://ncbi.nlm.nih.gov/pubmed/32505195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-020-00345-9
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