Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn’s disease

Angiotensin-Converting Enzyme 2 (ACE2) has been identified as the host receptor for SARS-coronavirus 2 (SARS-CoV-2) which has infected millions world-wide and likely caused hundreds of thousands of deaths. Utilizing transcriptomic data from four cohorts taken from Crohn’s disease (CD) and non-inflam...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:medRxiv
المؤلفون الرئيسيون: Potdar, Alka A., Dube, Shishir, Naito, Takeo, Botwin, Gregory, Haritunians, Talin, Li, Dalin, Yang, Shaohong, Bilsborough, Janine, Denson, Lee A., Daly, Mark, Targan, Stephan R., Fleshner, Phillip, Braun, Jonathan, Kugathasan, Subra, Stappenbeck, Thaddeus S., McGovern, Dermot P.B.
التنسيق: Artigo
اللغة:Inglês
منشور في: Cold Spring Harbor Laboratory 2020
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276052/
https://ncbi.nlm.nih.gov/pubmed/32511625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.04.19.20070995
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