Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn’s disease

Angiotensin-Converting Enzyme 2 (ACE2) has been identified as the host receptor for SARS-coronavirus 2 (SARS-CoV-2) which has infected millions world-wide and likely caused hundreds of thousands of deaths. Utilizing transcriptomic data from four cohorts taken from Crohn’s disease (CD) and non-inflam...

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Bibliografski detalji
Izdano u:medRxiv
Glavni autori: Potdar, Alka A., Dube, Shishir, Naito, Takeo, Botwin, Gregory, Haritunians, Talin, Li, Dalin, Yang, Shaohong, Bilsborough, Janine, Denson, Lee A., Daly, Mark, Targan, Stephan R., Fleshner, Phillip, Braun, Jonathan, Kugathasan, Subra, Stappenbeck, Thaddeus S., McGovern, Dermot P.B.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276052/
https://ncbi.nlm.nih.gov/pubmed/32511625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.04.19.20070995
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