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Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn’s disease

Angiotensin-Converting Enzyme 2 (ACE2) has been identified as the host receptor for SARS-coronavirus 2 (SARS-CoV-2) which has infected millions world-wide and likely caused hundreds of thousands of deaths. Utilizing transcriptomic data from four cohorts taken from Crohn’s disease (CD) and non-inflam...

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Detalhes bibliográficos
Publicado no:medRxiv
Main Authors: Potdar, Alka A., Dube, Shishir, Naito, Takeo, Botwin, Gregory, Haritunians, Talin, Li, Dalin, Yang, Shaohong, Bilsborough, Janine, Denson, Lee A., Daly, Mark, Targan, Stephan R., Fleshner, Phillip, Braun, Jonathan, Kugathasan, Subra, Stappenbeck, Thaddeus S., McGovern, Dermot P.B.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276052/
https://ncbi.nlm.nih.gov/pubmed/32511625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.04.19.20070995
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