Metabolic characteristics of CD8(+) T cell subsets in young and aged individuals are not predictive of functionality

Virtual memory T (T(VM)) cells are antigen-naïve CD8(+) T cells that exist in a semi-differentiated state and exhibit marked proliferative dysfunction in advanced age. High spare respiratory capacity (SRC) has been proposed as a defining metabolic characteristic of antigen-experienced memory T (T(ME...

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Publicado no:Nat Commun
Main Authors: Quinn, Kylie M., Hussain, Tabinda, Kraus, Felix, Formosa, Luke E., Lam, Wai K., Dagley, Michael J., Saunders, Eleanor C., Assmus, Lisa M., Wynne-Jones, Erica, Loh, Liyen, van de Sandt, Carolien E., Cooper, Lucy, Good-Jacobson, Kim L., Kedzierska, Katherine, Mackay, Laura K., McConville, Malcolm J., Ramm, Georg, Ryan, Michael T., La Gruta, Nicole L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275080/
https://ncbi.nlm.nih.gov/pubmed/32504069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16633-7
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