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H-Ras Transformation of Mammary Epithelial Cells Induces ERK-Mediated Spreading on Low Stiffness Matrix

Oncogenic transformation of mammary epithelial cells (MECs) is a critical step in epithelial-to-mesenchymal transition (EMT), but evidence also shows that MECs undergo EMT with increasing matrix stiffness; the interplay of genetic and environmental effects on EMT is not clear. To understand their co...

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Détails bibliographiques
Publié dans:Adv Healthc Mater
Auteurs principaux: Plunkett, Christopher, Kumar, Aditya, Yrastorza, Jaime, Hou, Yang-Hsun, Placone, Jesse, Grennan, Gillian, Engler, Adam J.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274860/
https://ncbi.nlm.nih.gov/pubmed/31951109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201901366
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