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Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene

Sphingosine-1-phosphate (S1P) is an anabolic clastokine. Colony Stimulating Factor 1 (CSF1) induces expression of the rate limiting enzyme required for S1P synthesis, sphingosine kinase 1 (SPHK1) in bone in vivo, and in osteoclasts in vitro. To study the mechanism of CSF1-induced SPHK1 gene expressi...

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Detalhes bibliográficos
Publicado no:Calcif Tissue Int
Main Authors: Yao, Gang Qing, Zhu, Meiling, Walker, Joanne, Insogna, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274855/
https://ncbi.nlm.nih.gov/pubmed/32246175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-020-00685-4
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