Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer

Tumor-associated macrophages (TAMs) influence lung tumor development by inducing immunosuppression. Transcriptome analysis of TAMs isolated from human lung tumor tissues revealed an up-regulation of the Wnt/β-catenin pathway. These findings were reproduced in a newly developed in vitro “trained” TAM...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Sarode, Poonam, Zheng, Xiang, Giotopoulou, Georgia A., Weigert, Andreas, Kuenne, Carste, Günther, Stefan, Friedrich, Aleksandra, Gattenlöhner, Stefan, Stiewe, Thorsten, Brüne, Bernhard, Grimminger, Friedrich, Stathopoulos, Georgios T., Pullamsetti, Soni Savai, Seeger, Werner, Savai, Rajkumar
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274802/
https://ncbi.nlm.nih.gov/pubmed/32548260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz6105
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