Stimulation of GLP-1 Receptor Inhibits Methylglyoxal-Induced Mitochondrial Dysfunctions in H9c2 Cardiomyoblasts: Potential Role of Epac/PI3K/Akt Pathway

Accumulation of methylglyoxal (MG) contributes to oxidative stress, apoptosis, and mitochondrial dysfunction, leading to the development of type 2 diabetes and cardiovascular diseases. Inhibition of mitochondrial abnormalities induced by MG in the heart may improve and delay the progression of heart...

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Vydáno v:Front Pharmacol
Hlavní autoři: Nuamnaichati, Narawat, Mangmool, Supachoke, Chattipakorn, Nipon, Parichatikanond, Warisara
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274035/
https://ncbi.nlm.nih.gov/pubmed/32547400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00805
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