Protection From Influenza by Intramuscular Gene Vector Delivery of a Broadly Neutralizing Nanobody Does Not Depend on Antibody Dependent Cellular Cytotoxicity

Cross-subtype neutralizing single domain antibodies against influenza present new opportunities for immunoprophylaxis and pandemic preparedness. Their simple modular structure and single open reading frame format are highly amenable to gene therapy-mediated delivery. We have previously described R1a...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Del Rosario, Joanne Marie M., Smith, Matthew, Zaki, Kam, Risley, Paul, Temperton, Nigel, Engelhardt, Othmar G., Collins, Mary, Takeuchi, Yasuhiro, Hufton, Simon E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7273724/
https://ncbi.nlm.nih.gov/pubmed/32547534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00627
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