A Novel MFS-MDR Transporter, MdrP, Employs D223 as a Key Determinant in the Na(+) Translocation Coupled to Norfloxacin Efflux

Multidrug resistance (MDR) transporters of the major facilitator superfamily (MFS) were previously believed to drive the extrusion of multiple antimicrobial drugs through the coupling to proton translocation. Here, we present the identification of the first Na(+)-coupled MFS-MDR transporter, MdrP, w...

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Vydáno v:Front Microbiol
Hlavní autoři: Zhang, Rui, Abdel-Motaal, Heba, Zou, Qiao, Guo, Sijia, Zheng, Xiutao, Wang, Yuting, Zhang, Zhenglai, Meng, Lin, Xu, Tong, Jiang, Juquan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272687/
https://ncbi.nlm.nih.gov/pubmed/32547505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.00955
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