Cytotoxic and genotoxic evaluation of cotinine using human neuroblastoma cells (SH-SY5Y)

Cotinine is the main metabolite of nicotine, which is metabolized in the liver through a cytochrome P450 enzyme. Different studies point to genetic instability caused by nicotine, such as single and double DNA strand breaks and micronuclei formation, but little is known about the effect of cotinine....

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Bibliografiske detaljer
Udgivet i:Genet Mol Biol
Main Authors: Dalberto, Daiana, Nicolau, Caroline Cardoso, Garcia, Ana Leticia Hilario, Nordin, Adriane Perachi, Grivicich, Ivana, da Silva, Juliana
Format: Artigo
Sprog:Inglês
Udgivet: Sociedade Brasileira de Genética 2020
Fag:
Mutagenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271658/
https://ncbi.nlm.nih.gov/pubmed/32478795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1678-4685-GMB-2019-0123
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