Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types

Innate drug sensitivity in healthy cells aids identification of lineage specific anti-cancer therapies and reveals off-target effects. To characterize the diversity in drug responses in the major hematopoietic cell types, we simultaneously assessed their sensitivity to 71 small molecules utilizing a...

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Publicat a:Haematologica
Autors principals: Majumder, Muntasir M., Leppä, Aino-Maija, Hellesøy, Monica, Dowling, Paul, Malyutina, Alina, Kopperud, Reidun, Bazou, Despina, Andersson, Emma, Parsons, Alun, Tang, Jing, Kallioniemi, Olli, Mustjoki, Satu, O’Gorman, Peter, Wennerberg, Krister, Porkka, Kimmo, Gjertsen, Bjørn T., Heckman, Caroline A.
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2020
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271564/
https://ncbi.nlm.nih.gov/pubmed/31439679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.217414
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