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Cholesterol Induces Nrf-2- and HIF-1α-Dependent Hepatocyte Proliferation and Liver Regeneration to Ameliorate Bile Acid Toxicity in Mouse Models of NASH and Fibrosis

Nonalcoholic steatohepatitis (NASH) is currently one of the most common liver diseases worldwide. The toxic effects of lipids and bile acids contribute to NASH. The regenerative pathway in response to damage to the liver includes activation of the inflammatory process and priming of hepatocytes to p...

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Publicat a:Oxid Med Cell Longev
Autors principals: Kaminsky-Kolesnikov, Yula, Rauchbach, Einat, Abu-Halaka, Diana, Hahn, Michal, García-Ruiz, Carmen, Fernandez-Checa, Jose C., Madar, Zecharia, Tirosh, Oren
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271232/
https://ncbi.nlm.nih.gov/pubmed/32566088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5393761
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