Cholesterol Induces Nrf-2- and HIF-1α-Dependent Hepatocyte Proliferation and Liver Regeneration to Ameliorate Bile Acid Toxicity in Mouse Models of NASH and Fibrosis

Nonalcoholic steatohepatitis (NASH) is currently one of the most common liver diseases worldwide. The toxic effects of lipids and bile acids contribute to NASH. The regenerative pathway in response to damage to the liver includes activation of the inflammatory process and priming of hepatocytes to p...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Kaminsky-Kolesnikov, Yula, Rauchbach, Einat, Abu-Halaka, Diana, Hahn, Michal, García-Ruiz, Carmen, Fernandez-Checa, Jose C., Madar, Zecharia, Tirosh, Oren
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271232/
https://ncbi.nlm.nih.gov/pubmed/32566088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5393761
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