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Reducing stress PERKs up anti-tumor immunity
Myeloid-derived suppressor cells (MDSC) can promote tumor progression. In this issue of Immunity, Mohamed et al. (2020) show that the unfolded protein response sensor, PERK, enhances MDSC-mediated immunosuppression through the NRF2 transcription factor, preventing oxidative damage, mitochondrial DNA...
Enregistré dans:
| Publié dans: | Immunity |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7271120/ https://ncbi.nlm.nih.gov/pubmed/32294402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.03.012 |
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