Metformin attenuates TGF-β1-induced pulmonary fibrosis through inhibition of transglutaminase 2 and subsequent TGF-β pathways

The purpose of this study was to confirm whether metformin can attenuate TGF-β1-induced pulmonary fibrosis through inhibition of transglutaminase 2 (TG2) and subsequent TGF-β pathways. In vitro, MTT assay and Annexin V-FITC/PI staining assay were performed to determine the effect of metformin on the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:3 Biotech
Hauptverfasser: Wang, Yubo, Lin, Caiyu, Han, Rui, Lu, Conghua, Li, Li, Hu, Chen, Feng, Mingxia, Chen, Hengyi, He, Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7270224/
https://ncbi.nlm.nih.gov/pubmed/32550106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13205-020-02278-2
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