Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities

Brain-derived neurotrophic factor (BDNF) signals through its high affinity receptor Tropomyosin receptor kinase-B (TrkB) to regulate neuronal development, synapse formation and plasticity. In rodents, genetic disruption of Bdnf and TrkB leads to weight gain and a spectrum of neurobehavioural phenoty...

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Publicado no:Sci Rep
Main Authors: Sonoyama, Takuhiro, Stadler, Lukas K. J., Zhu, Mingyan, Keogh, Julia M., Henning, Elana, Hisama, Fuki, Kirwan, Peter, Jura, Magdalena, Blaszczyk, Beata K., DeWitt, David C., Brouwers, Bas, Hyvönen, Marko, Barroso, Inês, Merkle, Florian T., Appleyard, Suzanne M., Wayman, Gary A., Farooqi, I. Sadaf
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7270116/
https://ncbi.nlm.nih.gov/pubmed/32493978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65531-x
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