Inhibition of calpain alleviates coxsackievirus B3-induced myocarditis through suppressing the canonical NLRP3 inflammasome/caspase-1-mediated and noncanonical caspase-11-mediated pyroptosis pathways

This study aimed to verify the effects of calpain on coxsackievirus B3 (CVB3)-induced myocarditis and to further explore the underlying mechanisms. Transgenic mice overexpressing calpastatin, the endogenous calpain inhibitor, were introduced in the present study. The murine model of viral myocarditi...

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Bibliographic Details
Published in:Am J Transl Res
Main Authors: Yu, Ying, Shi, Hui, Yu, Yong, Liu, Ming, Li, Minghui, Liu, Xiaoxiao, Wang, Yucheng, Chen, Ruizhen
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2020
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7270028/
https://ncbi.nlm.nih.gov/pubmed/32509190
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