Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA editing enzyme Adar1 is required for fear extinction

DNA forms conformational states beyond the right-handed double-helix; however, the functional relevance of these non-canonical structures in the brain remains unknown. We show that, in the prefrontal cortex of mice, the formation of one such structure, Z-DNA, is involved in the regulation of extinct...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Marshall, Paul R., Zhao, Qiongyi, Li, Xiang, Wei, Wei, Periyakaruppiah, Ambika, Zajaczkowski, Esmi L., Leighton, Laura J., Madugalle, Sachithrani U., Basic, Dean, Wang, Ziqi, Yin, Jiayu, Liau, Wei-Siang, Gupte, Ankita, Walkley, Carl R., Bredy, Timothy W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269834/
https://ncbi.nlm.nih.gov/pubmed/32367065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-020-0627-5
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