Oral N-acetylcysteine improves cone function in retinitis pigmentosa patients in phase I trial

BACKGROUND: In retinitis pigmentosa (RP), rod photoreceptors degenerate from 1 of many mutations, after which cones are compromised by oxidative stress. N-acetylcysteine (NAC) reduces oxidative damage and increases cone function/survival in RP models. We tested the safety, tolerability, and visual f...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Campochiaro, Peter A., Iftikhar, Mustafa, Hafiz, Gulnar, Akhlaq, Anam, Tsai, Grace, Wehling, Dagmar, Lu, Lili, Wall, G. Michael, Singh, Mandeep S., Kong, Xiangrong
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Clinical Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269599/
https://ncbi.nlm.nih.gov/pubmed/31805012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132990
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