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A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia
The drug efflux pump ABCB1 is a key driver of chemoresistance, and high expression predicts treatment failure in acute myeloid leukemia (AML). In this study, we identified and functionally validated the network of enhancers that controls expression of ABCB1. We show that exposure of leukemia cells t...
Guardat en:
| Publicat a: | J Clin Invest |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7269587/ https://ncbi.nlm.nih.gov/pubmed/31770110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130809 |
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