Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

Acute graft-versus-host disease (GVHD) can affect the central nervous system (CNS). The role of microglia in CNS-GVHD remains undefined. In agreement with microglia activation, we found that profound morphological changes and MHC-II and CD80 upregulation occurred upon GVHD induction. RNA sequencing–...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Mathew, Nimitha R., Vinnakota, Janaki M., Apostolova, Petya, Erny, Daniel, Hamarsheh, Shaimaa, Andrieux, Geoffroy, Kim, Jung-Seok, Hanke, Kathrin, Goldmann, Tobias, Chappell-Maor, Louise, El-Khawanky, Nadia, Ihorst, Gabriele, Schmidt, Dominik, Duyster, Justus, Finke, Jürgen, Blank, Thomas, Boerries, Melanie, Blazar, Bruce R., Jung, Steffen, Prinz, Marco, Zeiser, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269577/
https://ncbi.nlm.nih.gov/pubmed/31846439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130272
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