Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α

Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and in vivo models of ischemic injury that treatment with GLP-1(28–36), a neutral endopeptidase–generated (NEP-generated) metabolite of GLP-1, was as cardioprotective as G...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Siraj, M. Ahsan, Mundil, Dhanwantee, Beca, Sanja, Momen, Abdul, Shikatani, Eric A., Afroze, Talat, Sun, Xuetao, Liu, Ying, Ghaffari, Siavash, Lee, Warren, Wheeler, Michael B., Keller, Gordon, Backx, Peter, Husain, Mansoor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269572/
https://ncbi.nlm.nih.gov/pubmed/31985487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99934
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