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Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis

Spectinomycin is a ribosome-binding antibiotic that blocks the translocation step of translation. A prevalent resistance mechanism is modification of the drug by aminoglycoside nucleotidyl transferase (ANT) enzymes of the spectinomycin-specific ANT(9) family or by enzymes of the dual-specificity ANT...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Kanchugal P, Sandesh, Selmer, Maria
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269491/
https://ncbi.nlm.nih.gov/pubmed/32253216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00371-20
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