Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity

BACKGROUND: Consecutive testing of single nucleotide polymorphisms (SNPs) is usually employed to identify genetic variants associated with complex traits. Ideally one should model all covariates in unison, but most existing analysis methods for genome-wide association studies (GWAS) perform only uni...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Gigascience
Hauptverfasser: Chu, Benjamin B, Keys, Kevin L, German, Christopher A, Zhou, Hua, Zhou, Jin J, Sobel, Eric M, Sinsheimer, Janet S, Lange, Kenneth
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Technical Note
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7268817/
https://ncbi.nlm.nih.gov/pubmed/32491161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gigascience/giaa044
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