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Optimization of hydrogenobyrinic acid biosynthesis in Escherichia coli using multi-level metabolic engineering strategies
BACKGROUND: Hydrogenobyrinic acid is a key intermediate of the de-novo aerobic biosynthesis pathway of vitamin B(12). The introduction of a heterologous de novo vitamin B(12) biosynthesis pathway in Escherichia coli offers an alternative approach for its production. Although E. coli avoids major lim...
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| Publicado no: | Microb Cell Fact |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7268678/ https://ncbi.nlm.nih.gov/pubmed/32487216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-020-01377-2 |
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