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Changes to aspects of ongoing randomised controlled trials with fixed designs

BACKGROUND: Despite careful planning, changes to some aspects of an ongoing randomised clinical trial (RCT), with a fixed design, may be warranted. We sought to elucidate the distinction between legitimate versus illegitimate changes to serve as a guide for less experienced clinical trialists and ot...

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Detalhes bibliográficos
Publicado no:Trials
Main Authors: Coskinas, Xanthi, Simes, John, Schou, Manjula, Martin, Andrew James
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7268339/
https://ncbi.nlm.nih.gov/pubmed/32493444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-020-04374-3
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