Tetravalent dengue DNA vaccine is not immunogenic when delivered by retrograde infusion into salivary glands

INTRODUCTION AND BACKGROUND: A tetravalent DNA vaccine for Dengue virus is under development but has not yet achieved optimal immunogenicity. Salivary glands vaccination has been reported efficacious in rodents and dogs. We report on a pilot study testing the salivary gland as a platform for a Dengu...

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Publié dans:Trop Dis Travel Med Vaccines
Auteurs principaux: El Helou, Guy, Ponzio, Todd A., Goodman, Joseph F., Blevins, Maria, Caudell, David L., Raviprakash, Kanakatte S., Ewing, Daniel, Williams, Maya, Porter, Kevin R., Sanders, John W.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Short Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7268334/
https://ncbi.nlm.nih.gov/pubmed/32518668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40794-020-00111-5
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