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Interpretable factor models of single-cell RNA-seq via variational autoencoders

MOTIVATION: Single-cell RNA-seq makes possible the investigation of variability in gene expression among cells, and dependence of variation on cell type. Statistical inference methods for such analyses must be scalable, and ideally interpretable. RESULTS: We present an approach based on a modificati...

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Detalles Bibliográficos
Publicado en:Bioinformatics
Main Authors: Svensson, Valentine, Gayoso, Adam, Yosef, Nir, Pachter, Lior
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7267837/
https://ncbi.nlm.nih.gov/pubmed/32176273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa169
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