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Interpretable factor models of single-cell RNA-seq via variational autoencoders

MOTIVATION: Single-cell RNA-seq makes possible the investigation of variability in gene expression among cells, and dependence of variation on cell type. Statistical inference methods for such analyses must be scalable, and ideally interpretable. RESULTS: We present an approach based on a modificati...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Bioinformatics
Egile Nagusiak: Svensson, Valentine, Gayoso, Adam, Yosef, Nir, Pachter, Lior
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7267837/
https://ncbi.nlm.nih.gov/pubmed/32176273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa169
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